Endocrine Abstracts

Insulin resistance (IR) may be defined as the physiological condition, in which insulin signaling is somehow deranged somewhat irreversibly such that insulin is of little use to cells or tissues. Specific roles of insulin are quite different in the muscle tissue, adipose tissue, and liver. Accordingly, detailed aspects of IR would be very tissue-specific. Meanwhile, IR may develop first in the muscle tissue with a relatively low cell turnover and then progress, in sequence, to...